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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > (E)-NecrosulfonamideCAS：1360614-48-7
Molecular Formula：C18H15N5O6S2
Molecular Weight：461.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1360614-48-7 |
| Name | (E)-Necrosulfonamide |
| Molecular Formula | C18H15N5O6S2 |
| Molecular Weight | 461.47 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| MDL | MFCD02370191 |
| SMILES | O=C(NC1=CC=C(S(=O)(NC2=NC=CN=C2OC)=O)C=C1)/C=C/C3=CC=C([N+]([O-])=O)S3.[(E)] |
| InChIKey | FNPPHVLYVGMZMZ-XBXARRHUSA-N |
| InChI | InChI=1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+ |
| PubChem CID | 1566236 |
| Target Point | Necroptosis;Mixed lineage kinases (MLKs) |
| Passage | Apoptosis;MAPK |
| Background | Necrosulfonamide is a specific and potent necrosis inhibitor that exerts its effects by inhibiting mLKL. |
| Biological Activity | Necrosulfonamide (NSA)是一种有效的小分子necroptosis抑制剂。应用正向化学遗传学方法，利用基于NSA的化学探针进一步揭示NSA选择性地靶向混合谱系激酶结构域样蛋白（MLKL）以阻断坏死小体的形成。[1] |
| Data Literature Source | [1] Daohong Liao，et al. Med Chem Commun. 2014，5，333. [2] Sun L，et al. Cell. 2012，148(1-2):213-27. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Alfhili MA, et. . Int J Occup Med Environ Health. 2022 Feb 15;35(1):1-11. doi: 10.13075/ijomeh.1896.01814.
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Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling.
Click to check >>Author：Alfhili MA, Alamri HS, Alsughayyir J, Basudan AM.
IF：1.6760
Publish_to：Int J Occup Med Environ Health.
PMID：34524276
INDUCTION OF HEMOLYSIS AND ERYPTOSIS BY OCCUPATIONAL POLLUTANT NICKEL CHLORIDE IS?MEDIATED THROUGH CALCIUM INFLUX AND P38 MAP KINASE SIGNALING
Click to check >>Author：MOHAMMAD A. ALFHILI
IF：1.5410
Publish_to：
PMID：34524276
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