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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > ABT-737CAS：852808-04-9
Molecular Formula：C42H45ClN6O5S2
Molecular Weight：813.43
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 852808-04-9 |
| Name | ABT-737 |
| Molecular Formula | C42H45ClN6O5S2 |
| Molecular Weight | 813.43 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| MDL | MFCD12756212 |
| SMILES | CN(CC[C@@H](NC1=CC=C(C=C1[N+]([O-])=O)S(NC(C2=CC=C(C=C2)N3CCN(CC3)CC4=CC=CC=C4C5=CC=C(C=C5)Cl)=O)(=O)=O)CSC6=CC=CC=C6)C |
| InChIKey | HPLNQCPCUACXLM-PGUFJCEWSA-N |
| InChI | InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1 |
| PubChem CID | 11228183 |
| Target Point | Bcl-2 Family;Bcl-B;Bcl-w;Bcl-xL |
| Passage | Apoptosis |
| Background | ABT-737 is a BH3-like inhibitor of Bcl-xL, Bcl-2 and Bcl-w. |
| Biological Activity | ABT-737 是一种类似 BH3 的 Bcl-xL, Bcl-2 和 Bcl-w 的抑制剂, EC50 值分别为 78.7 nM, 30.3 nM 和 197.8 nM[1-3]。 |
| IC50 | Bcl-2:30.3nM (EC50) Bcl-xL:78.7nM (EC50) Bcl-W:197.8nM (EC50) Bcl-B:1820nM (EC50) [1-3] |
| Data Literature Source | [1]. Sun XP， et al. ABT-737 Synergizes with Arsenic Trioxide to Induce Apoptosis of Gastric Carcinoma Cells In Vitro and In Vivo.J Int Med Res. 2012; 40 (4) :1251-64. [2]. Clerc P， et al. Polster BM.Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry.PLoS One. 2012; 7 (8) :e42487. Epub 2012 Aug 3. [3]. Konopleva M， et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov; 10 (5) :375-88 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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