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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > AcadesineCAS：2627-69-2
Molecular Formula：C9H14N4O5
Molecular Weight：258.23
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 2627-69-2 |
| Name | Acadesine |
| Molecular Formula | C9H14N4O5 |
| Molecular Weight | 258.23 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 220-097-5 |
| MDL | MFCD00869751 |
| SMILES | OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC(C(N)=O)=C2N)O1 |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| InChI | InChI=1S/C9H14N4O5/c10-7-4(8(11)17)12-2-13(7)9-6(16)5(15)3(1-14)18-9/h2-3,5-6,9,14-16H,1,10H2,(H2,11,17)/t3-,5-,6-,9-/m1/s1 |
| PubChem CID | 17513 |
| Target Point | AMPK;Autophagy;YAP;Mitophagy |
| Passage | PI3K/Akt/mTOR;Epigenetics |
| Background | Acadisine is an adenosine analog and an AMPK activator. Acadisine is also an autophagy, YAP and mitophagy inhibitor. |
| Biological Activity | AICAR是一种可渗透细胞的AMP活化蛋白激酶 (AMPK) 激活剂。[1-4] |
| Data Literature Source | [1]. Nakamaru K， et al. AICAR， an activator of AMP-activated protein kinase， down-regulates the insulin receptor expression in HepG2 cells. Biochem Biophys Res Commun. 2005 Mar 11; 328 (2) :449-54 [2]. Drake JC， et al. AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2010 Dec; 299 (6) :R1546-54. [3]. Pold R， et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats.Diabetes. 2005 Apr; 54 (4) :928-34. [4]. Chen L， et al. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16; 9:761. |
| Unit | Bottle |
| Specification | 10mM*1mL in DMSO 50mg 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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