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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Aminooxyacetic acid hemiHydrochlorideCAS：2921-14-4
Molecular Formula：C2H5NO3·1/2HCl
Molecular Weight：109.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2921-14-4 |
| Name | Aminooxyacetic acid hemiHydrochloride |
| Molecular Formula | C2H5NO3·1/2HCl |
| Molecular Weight | 109.3 |
| Solubility | Soluble in Water/DMSO ≥40mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 220-862-3 |
| MDL | MFCD00012955 |
| SMILES | OC(CON)=O.[H]Cl.OC(CON)=O |
| InChIKey | KBXIJIPYZKPDRU-UHFFFAOYSA-N |
| InChI | InChI=1S/2C2H5NO3.ClH/c2*3-6-1-2(4)5;/h2*1,3H2,(H,4,5);1H |
| PubChem CID | 2723609 |
| Target Point | GABA Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | It is a malate-aspartate shuttle (MAS) inhibitor and also inhibits the GABA-degrading enzyme GABA-T. |
| Biological Activity | Aminooxyacetic acid hemihydrochloride 是苹果酸-天冬氨酸穿梭 (MAS) 抑制剂, 也能抑制 GABA 降解酶 GABA-T。[1-3] |
| Data Literature Source | [1]. Wang C，et al. Malate-aspartate shuttle inhibitor aminooxyacetic acid leads to decreased intracellular ATP levels and altered cell cycle of C6 glioma cells by inhibiting glycolysis. Cancer Lett. 2016 Aug 1;378(1):1-7. [2]. Pagliusi SR，et al. Aminooxyacetic acid induced accumulation of GABA in the rat brain. Interaction with GABA receptors and distribution in compartments. Naunyn Schmiedebergs Arch Pharmacol. 1983 Apr;322(3):210-5. [3]. Korangath P，et al. Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate. Clin Cancer Res. 2015 Jul 15;21(14):3263-73. |
| Unit | Bottle |
| Specification | 500mg 10mM*1mL in DMSO 10mM*1mL in Water 1g 2g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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