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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > ANA-12CAS：219766-25-3
Molecular Formula：C22H21N3O3S
Molecular Weight：407.49
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 219766-25-3 |
| Name | ANA-12 |
| Molecular Formula | C22H21N3O3S |
| Molecular Weight | 407.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 803-090-7 |
| MDL | MFCD00117444 |
| SMILES | O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O |
| InChIKey | TUSCYCAIGRVBMD-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H21N3O3S/c26-20(25-17-10-5-6-12-23-21(17)27)15-8-2-3-9-16(15)24-22(28)19-13-14-7-1-4-11-18(14)29-19/h1-4,7-9,11,13,17H,5-6,10,12H2,(H,23,27)(H,24,28)(H,25,26) |
| PubChem CID | 2799722 |
| Target Point | Trk Receptor |
| Passage | Protein Tyrosine Kinase/RTK;Neuronal Signaling |
| Background | ANA-12 is a potent, selective TrkB antagonist. |
| Biological Activity | ANA-12是有效，选择性的 TrkB 拮抗剂，对高亲和力和低亲和力位点的IC50 分别为45.6 nM和41.1 μM[1-4]。 |
| Data Literature Source | [1]. Cazorla M，et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57. [2]. Zhang JC，et al. Comparison of ketamine，7，8-dihydroxyflavone，and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology (Berl). 2015 Dec;232(23):4325-35. [3]. Vassoler FM，et al. Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci. 2013 Jan;16(1):42-7. [4]. Fang X，et al. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Eur Arch Psychiatry Clin Neurosci. 2018 Jun 7. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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