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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Amiloride Hydrochloride DihydrateCAS：17440-83-4
Molecular Formula：C6H8ClN7O·HCl·2H2O
Molecular Weight：302.12
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 17440-83-4 |
| Name | Amiloride Hydrochloride Dihydrate |
| Molecular Formula | C6H8ClN7O·HCl·2H2O |
| Molecular Weight | 302.12 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| Delivery Time | 1-2 Days |
| EC | EINECS 620-474-8 |
| SMILES | O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O |
| InChIKey | LTKVFMLMEYCWMK-UHFFFAOYSA-N |
| InChI | InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2 |
| PubChem CID | 68540 |
| Target Point | Sodium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | Amiloride Hydrochloride Dihydrate is an inhibitor of epithelial sodium channels (ENaC) and urokinase-type plasminogen activator receptor (uTPA), as well as polycystin-2 (PC2; TRPP2) channel blocker. |
| Biological Activity | Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel.[1-8] |
| Data Literature Source | [1] Kim KM，et al. Oncogene，005，24(3)，355-366. [2] Koivusalo M，et al. J Cell Biol，010，188(4)，547-563. [3] Karmazyn M，et al. Am J Physiol，988，255(3 Pt 2)，H608-615. [4] Besterman JM，et al. J Biol Chem，985，260(2)，1155-1159. [5] Soltoff SP，et al. Science，983，220(4600)，957-958. [6]. Miller RL，et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. [7]. Xu LB，et al. Amiloride，a urokinase-type plasminogen activator receptor (uTPA) inhibitor，reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29. [8]. Giamarchi A，et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91. |
| Unit | Bottle |
| Specification | 100mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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A Non-Lipolysis Nanoemulsion Improved Oral Bioavailability by Reducing the First-Pass Metabolism of Raloxifene, and Related Absorption Mechanisms Being Studied.
Click to check >>Author：Ye JY, Chen ZY, Huang CL, Huang B, Zheng YR, Zhang
IF：5.9290
Publish_to：Int J Nanomedicine.
PMID：32922013
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