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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > ChrysophanolCAS：481-74-3
Molecular Formula：C15H10O4
Molecular Weight：254.24
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Yellow to orange Solid
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| CAS | 481-74-3 |
| Name | Chrysophanol |
| Molecular Formula | C15H10O4 |
| Molecular Weight | 254.24 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | Yellow to orange Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-572-2 |
| MDL | MFCD00001208 |
| SMILES | O=C1C2=C(C=CC=C2O)C(C3=CC(C)=CC(O)=C13)=O |
| InChIKey | LQGUBLBATBMXHT-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O4/c1-7-5-9-13(11(17)6-7)15(19)12-8(14(9)18)3-2-4-10(12)16/h2-6,16-17H,1H3 |
| PubChem CID | 10208 |
| Target Point | EGFR;mTOR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; PI3K/AKT/mTOR |
| Background | It is an anthraquinone, an EGFR/mTOR inhibitor. |
| Biological Activity | Chrysophanol (Chrysophanic acid) 是一种天然蒽醌，抑制EGF-诱导的 EGFR 磷酸化，且抑制 AKT 和 mTOR/p70S6K 激活。[1-2] |
| Data Literature Source | [1]. Lee MS，et al. Chrysophanic acid blocks proliferation of colon cancer cells by inhibiting EGFR/mTOR pathway. Phytother Res. 2011 Jun;25(6):833-7. [2]. Lim H，et al. Chrysophanic Acid Suppresses Adipogenesis and Induces Thermogenesis by Activating AMP-Activated Protein Kinase Alpha In vivo and In vitro. Front Pharmacol. 2016 Dec 8;7:476. |
| Unit | Bottle |
| Specification | 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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