| CAS |
499-75-2 |
| Chinese Name |
香荆芥酚 |
| English Name |
Carvacrol |
| Synonyms |
cymophenol;O-Thymol;Karvakrol;香芹酚 |
| Molecular Formula |
C10H14O |
| Molecular Weight |
150.22 |
| Solubility |
Soluble in DMSO |
| Purity |
HPLC≥98% |
| Appearance |
Colorless to light yellow Liquid |
| Storage |
Store at 2-8℃，2 years |
| Density |
0.976g/mL |
| EC |
EINECS 207-889-6 |
| MDL |
MFCD00002236 |
| SMILES |
CC(C)C1=CC(O)=C(C)C=C1 |
| InChIKey |
RECUKUPTGUEGMW-UHFFFAOYSA-N |
| InChI |
InChI=1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4-7,11H,1-3H3 |
| PubChem CID |
10364 |
| Target Point |
Others |
| Passage |
Others |
| Background |
Carvacrol is a monoterpene phenol in the Lamiaceae plant with antioxidant, anti-inflammatory, and anticancer activities. Carvacrol causes G0/G1 cell cycle arrest, down-regulates Notch-1 and Jagged-1, and induces apoptosis. |
| Biological Activity |
Carvacrol (Cymophenol), monoterpenic phenol isomeric with thymol, has diverse activities such as antimicrobial, antitumor, an-timutagenic, antigenotoxic, analgesic, antispasmodic, anti-inflammatory, angiogenic, antiparasitic, antiplatelet, AChE inhibitory, antielastase, insecticidal, antihepatotoxic and hepatoprotective activities.[1-2] |
| In Vitro |
Carvacrol(CVC)possesses weak antioxidant and cytotoxic activity in cultured primary rat neurons. In addition，Carvacrol has weak antioxidant properties and little anticancer potentials in rat N2a neuroblastoma cell line[1]. Carvacrol is a novel inhibitor of transient receptor potential(TRP)channels in drosophila and mammalian. In human hepatoma HepG2 cells，Carvacrol induces cell apoptosis by selectively decreasing phosphorylation of extracellular signal-regulated kinase 1/2(ERK1/2)and P38; In human macrophage-like U937 cells，in response to lipopolysaccharide treatment，Carvacrol activates peroxisome proliferator-activated receptors(PPAR alpha and gamma)and suppresses cyclooxygenase-2(COX-2)mRNA and protein expression[2]. |
| In Vivo |
Carvacrol has the ability to protect liver against ischemia/reperfusion injury in rats. In the central nervous system，Carvacrol is regarded as a potential drug for Alzheimer's disease due to its inhibitory effect on acetylcholinesterase(AChE)activity by using phenolic hydroxyl group of carvacrol to bind to AChE and leading to a loss of function of AChE. In addition，Carvacrol is found to have an antidepressant-like effect in mice by affecting the dopaminergic system. Dietary carvacrol supplementation prevents high fat diet-induced obesity by modulating gene expressions that lead to adipogenesis and inflammation. Carvacrol crosses the blood-brain barrier easily and rapidly[2]. |
| Cell Experiment |
The cells are seeded in 48-well plates. Cells are incubated at 37 °C in a humidified 5 % CO2/95 % air mixture and treated with carvacrol at different concentrations(10，25，50，100，200 and 400 mg/L)for 24 h. MTT substrate solution is used. Briefly，MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide(DMSO)，MTT is added to the cell cultures for 3 h. Formed formazan crystals are dissolved in dimethyl sulfoxide(DMSO).[1] |
| Animal Experiment |
Animal Models: Male ICR mice; Dosages: 50 mg/kg; Administration: i.c.v.[2] |
| Data Literature Source |
[1] Elanur Ayd n，et al. Cytotechnology. 2014，66(1): 149–157.
[2] Yu H，et al. PLoS One. 2012，7(3):e33584. |
| Unit |
Bottle |
| Specification |
20mg 100mg 200mg |
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