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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > EcdysteroneCAS：5289-74-7
Molecular Formula：C27H44O7
Molecular Weight：480.63
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to yellow Solid
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| CAS | 5289-74-7 |
| Name | Ecdysterone |
| Molecular Formula | C27H44O7 |
| Molecular Weight | 480.63 |
| Solubility | Soluble in DMSO≥100mg/mL；Soluble in Ethanol≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 811-097-1 |
| MDL | MFCD00036740 |
| SMILES | O[C@@H]1[C@H](O)C[C@](C(C=C2[C@]3([H])CC[C@@]4(C)[C@@]2(O)CC[C@]4([H])[C@](O)(C)[C@H](O)CCC(O)(C)C)=O)([H])[C@]3(C)C1 |
| Target Point | Caspase; Autophagy |
| Passage | Apoptosis; Autophagy |
| Background | Ecdysone is an ecdysone that controls molting and metamorphosis in arthropods, inhibits caspase activity and induces autophagy through the 20E nuclear receptor complex EcR-USP. |
| Biological Activity | 20-Hydroxyecdysone (Ecdysterone, 20E, B-ecdysone, Commisterone, Crustecdysone) 是一种自然发生的蜕皮激素，控制节肢动物的蜕皮和变态。20-Hydroxyecdysone (Ecdysterone, 20E) 可抑制 caspase 活性并通过20E核受体复合体 EcR-USP 来诱导自噬。[1-5] |
| Data Literature Source | [1] Kizelsztein P，et al. Am J Physiol Endocrinol Metab，2009，296(3)，E433-439. [2] Hu J，et al. J Cell Biochem，2010，111(6)，1512-1521. [3] Peschel W，et al. J Pharm Pharmacol，2011，63(11)，1483-1495. [4] Tian L，et al. Arch Insect Biochem Physiol，2012，79(4-5)，207-219. [5] Hung TJ，et al. J Diabetes Complications，2012. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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The uncommon function and mechanism of the common enzyme glyceraldehyde-3-phosphate dehydrogenase in the metamorphosis of Helicoverpa armigera
Click to check >>Author：Zhao W; Zhang B; Geng Z; Chang Y; Wei J; An S
IF：5.7000
Publish_to：Front Bioeng Biotechnol
PMID：36329701
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