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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > EpiberberineCAS：6873/9/2
Molecular Formula：C20H18NO4
Molecular Weight：336.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Yellow to orange Solid
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| CAS | 6873/9/2 |
| Name | Epiberberine |
| Molecular Formula | C20H18NO4 |
| Molecular Weight | 336.36 |
| Solubility | Soluble in DMSO ≥10mg/mL;Soluble in Water ≥5mg/mL(Need ultrasonic or Water bath) |
| Purity | HPLC≥98% |
| Appearance | Yellow to orange Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01547982 |
| SMILES | COC1=C(OC)C=C2C(CC[N+]3=C2C=C(C=C4)C(C5=C4OCO5)=C3)=C1 |
| Target Point | AChE |
| Passage | Neuronal Signaling |
| Background | It is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor. |
| Biological Activity | Epiberberine 为有效的 AChE 和 BChE 抑制剂，和非竞争性的 BACE1 抑制剂，IC50 值分别为 1.07，6.03 和 8.55 μM。Epiberberine 具有抗氧化作用，能够清除 ONOO- (IC50，16.83 μM)，对阿尔滋海默症和糖尿病[3]有潜在治疗作用[1]。在 3T3-L1 细胞分化早期，Epiberberine 能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路[3]。 |
| IC50 | 1.07μM(AChE)，6.03μM(BChE)，8.55μM(BACE1)[2] |
| Data Literature Source | [1]. Jung HA，et al. Anti-Alzheimer and antioxidant activities of Coptidis Rhizoma alkaloids. Biol Pharm Bull. 2009 Aug;32(8):1433-8. [2]. Choi JS，et al. Anti-adipogenic effect of epiberberine is mediated by regulation of the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways. Arch Pharm Res. 2015 Dec;38(12):2153-62. [3]. Ma H，et al. Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK-Ay Mice. Drug Dev Res. 2016 Jun;77(4):163-70. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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