English Name |
Anti-EFEMP2 Polyclonal Antibody |
Chinese Name |
含有纤维蛋白样细胞外基质蛋白2抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
WB 1:500-1000. IP 0.5-4.0 ug for IP and 1:500-1000 for WB. IHC 1:20-200. |
Target |
EFEMP2 |
Synonyms |
EFEMP 2, EFEMP2, EGF containing fibulin like extracellular matrix protein 2, EGF-containing fibulin-like extracellular matrix protein 2, FBLN 4, FBLN4, FBLN4_HUMAN, FIBL 4, FIBL-4, FIBL4, Fibulin 4, Fibulin-4, MBP 1, MBP1, Mutant p53 binding protein 1, Protein UPH1, UPH 1, UPH1, UPH1 protein |
Background |
Fibulin proteins contribute to normal development of elastic fiber systems in various types of organs that require elasticity, such as vasculature, lung and skin. Fibulin-4, also known as EFEMP2 (EGF-containing fibulin-like extracellular matrix protein 2), MBP1 or UPH1 is a 443 amino acid secreted protein that contains six EGF-like calcium-binding domains and belongs to the fibulin family. Expressed ubiquitously with highest expression in heart, Fibulin-4 is essential for connective tissue development and elastic fiber formation, and may also play an important role in vascular patterning and collagen biosynthesis. Defects in the gene encoding Fibulin-4 are associated with autosomal recessive cutis laxa type I (CL type I), a connective tissue disorder that is inherited in both an autosomal dominant and an autosomal recessive manner and is characterized by inelastic tissue in all affected areas of the body. |
Swiss Prot |
O95967 |
Gene ID |
30008 |
Subcellular Location |
Secreted |
Immunogen |
Recombinant protein of human EFEMP2 |
Public Immunogen Range |
144-443aa |
Calculated MW |
49kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Mouse Human |
Application |
ELISA IP IHC WB |