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AZD-7762

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Cat.No：IA1660 Solarbio

CAS：860352-01-8

Molecular Formula：C₁₇H₁₉FN₄O₂S

Molecular Weight：362.42

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	860352-01-8
Name	AZD-7762
Molecular Formula	C₁₇H₁₉FN₄O₂S
Molecular Weight	362.42
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD12406007
SMILES	O=C(N[C@@H]1CNCCC1)C2=C(C=C(S2)C3=CC=CC(F)=C3)NC(N)=O
InChIKey	IAYGCINLNONXHY-LBPRGKRZSA-N
InChI	InChI=1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24)/t12-/m0/s1
PubChem CID	11152667
Target Point	Checkpoint Kinase (Chk)
Passage	Cell Cycle
Background	AZD-7762 is a potent ATP-competitive cell cycle checkpoint kinase (Chk) inhibitor.
Biological Activity	AZD-7762 是一种有效的ATP竞争性的Checkpoint kinase(Chk) 抑制剂，抑制Chk1的 IC50 为 5 nM[1-2]。
IC50	Chk1:5nM;Chk2:5nM [1-2]
Data Literature Source	[1]. Zabludoff SD，et al. AZD7762，a novel checkpoint kinase inhibitor，drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol Cancer Ther. 2008 Sep;7(9):2955-66. [2]. Quin J，et al. Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling. Oncotarget. 2016 Aug 2;7(31):49800-49818.
Unit	Piece
Specification	5mg 10mM*1mL in DMSO 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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