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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > GSK 3 Inhibitor IXCAS：667463-62-9
Molecular Formula：C16H10BrN3O2
Molecular Weight：356.17
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 667463-62-9 |
| Name | GSK 3 Inhibitor IX |
| Molecular Formula | C16H10BrN3O2 |
| Molecular Weight | 356.17 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08705318 |
| SMILES | O/N=C(C1=CC=CC=C1N2)/C2=C3C(NC4=C/3C=CC(Br)=C4)=O |
| InChIKey | SAQUSDSPQYQNBG-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H |
| PubChem CID | 448949 |
| Target Point | GSK-3;CDK |
| Passage | PI3K/Akt/mTOR;Stem Cells |
| Background | GSK 3 Inhibitor IX is a potent, selective, reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complexes. |
| Biological Activity | GSK 3 Inhibitor IX 是一种有效的，选择性的，可逆的，ATP 竞争性的 GSK-3α/β 和 CDK1-cyclinB 复合体抑制剂，能够抑制 (GSK-3α/β)/CDK1/CDK5 的活性，IC50 值分别为 5 nM/320 nM/83 nM[1-4]。 |
| Data Literature Source | [1]. Meijer L，et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66. [2]. Sato N，et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med. 2004 Jan;10(1):55-63. Epub 2003 Dec 21. [3]. Tseng AS，et al. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem Biol. 2006 Sep;13(9):957-63. [4]. Liu L1，et al. 6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res. 2011 Jun 1;71(11):3972-9 |
| Unit | Piece |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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