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Capmatinib

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Cat.No：IC1620 Solarbio

CAS：1029712-80-8

Molecular Formula：C₂₃H₁₇FN₆O

Molecular Weight：412.42

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1029712-80-8
Name	Capmatinib
Molecular Formula	C₂₃H₁₇FN₆O
Molecular Weight	412.42
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 813-241-9
MDL	MFCD18633285
SMILES	O=C(NC)C1=CC=C(C2=NN3C(N=C2)=NC=C3CC4=CC=C5N=CC=CC5=C4)C=C1F
InChIKey	LIOLIMKSCNQPLV-UHFFFAOYSA-N
InChI	InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
PubChem CID	25145656
Target Point	c-Met/HGFR
Passage	Protein Tyrosine Kinase/RTK
Background	Capmatinib is a potent and selective c-MET kinase inhibitor.
Biological Activity	Capmatinib 是一种有效的选择性c-MET 激酶抑制剂。Capmatinib 抑制 c-MET 激酶活性，平均IC50 为 0.13 nM[1]。
IC50	0.13nM(c-MET)[1]
Data Literature Source	[1]. Liu X，et al. A novel kinase inhibitor，INCB28060，blocks c-MET-dependent signaling，neoplastic activities，and cross-talk with EGFR and HER-3. Clin Cancer Res. 2011 Nov 15;17(22):7127-38
Unit	Piece
Specification	10mg 20mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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