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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > CediranibCAS：288383-20-0
Molecular Formula：C25H27FN4O3
Molecular Weight：450.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 288383-20-0 |
| Name | Cediranib |
| Molecular Formula | C25H27FN4O3 |
| Molecular Weight | 450.51 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 670-946-2 |
| MDL | MFCD09954115 |
| SMILES | FC1=C(OC2=C(C(C=C3OCCCN4CCCC4)=NC=N2)C=C3OC)C=CC5=C1C=C(C)N5 |
| InChIKey | XXJWYDDUDKYVKI-UHFFFAOYSA-N |
| InChI | InChI=1S/C25H27FN4O3/c1-16-12-17-19(29-16)6-7-21(24(17)26)33-25-18-13-22(31-2)23(14-20(18)27-15-28-25)32-11-5-10-30-8-3-4-9-30/h6-7,12-15,29H,3-5,8-11H2,1-2H3 |
| PubChem CID | 9933475 |
| Target Point | VEGFR2 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK |
| Background | It is a highly selective VEGFR2 inhibitor. |
| Biological Activity | Cediranib maleate (AZD-2171 maleate) 是高选择性的 VEGFR2 抑制剂, 对Flt1, KDR, Flt4, PDGFRα, PDGFRβ, c-Kit的 IC50 值分别为小于1, 小于3, 5, 5, 36, 2nM[1-2]。 |
| IC50 | Flt-1:5nM (IC50) KDR:1nM (IC50) Flt-4:3nM (IC50) PDGFRα:36nM (IC50) PDGFRβ:5nM (IC50) c-Kit:2nM (IC50) [1-2] |
| Data Literature Source | [1]. Wedge SR， et al. AZD2171: a highly potent， orally bioavailable， vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res， 2005， 65 (10) ， 4389-4400. [2]. Zhang L， et al. Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas. Sci Signal. 2015 Dec 8; 8 (406) :ra125 |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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