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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > CUDC-101CAS：1012054-59-9
Molecular Formula：C24H26N4O4
Molecular Weight：434.49
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1012054-59-9 |
| Name | CUDC-101 |
| Molecular Formula | C24H26N4O4 |
| Molecular Weight | 434.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD15528940 |
| SMILES | C#CC1=CC=CC(NC2=NC=NC3=CC(OC)=C(C=C23)OCCCCCCC(NO)=O)=C1 |
| InChIKey | PLIVFNIUGLLCEK-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H26N4O4/c1-3-17-9-8-10-18(13-17)27-24-19-14-22(21(31-2)15-20(19)25-16-26-24)32-12-7-5-4-6-11-23(29)28-30/h1,8-10,13-16,30H,4-7,11-12H2,2H3,(H,28,29)(H,25,26,27) |
| PubChem CID | 24756910 |
| Target Point | EGFR;HDAC;HER2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | CUDC-101 is a potent HDAC, EGFR and HER2 inhibitor. |
| Biological Activity | CUDC-101 是一种高效的 HDAC、EGFR 和 HER2 抑制剂，对应的 IC50 值分别为 4.4、2.4 和 15.7 nM[1-4]。 |
| Data Literature Source | [1]. Xiong Cai et al Discovery of 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDC-101) as a Potent Multi-Acting HDAC，EGFR，and HER2 Inhibitor for the Treatment of Cancer J. Med. Chem.，2010，53 (5)，pp 2000–2009 [2]. Sun H，et al. CUDC-101，a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy. Horm Cancer. 2016 Jun;7(3):196-210. [3]. Zhang L，et al. Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer. Oncotarget. 2015 Apr 20;6(11):9073-85. [4]. Lai CJ，et al. CUDC-101，a multitargeted inhibitor of histone deacetylase，epidermal growth factor receptor，and human epidermal growth factor receptor 2，exerts potent anticancer activity.Cancer Res. 2010 May 1;70(9):3647-56. Epub 2010 Apr 13 |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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