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Dynasore

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Cat.No：ID1010 Solarbio

CAS：304448-55-3

Molecular Formula：C₁₈H₁₄N₂O₄

Molecular Weight：322.31

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light brown to brown Solid

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Product Information

CAS	304448-55-3
Name	Dynasore
Molecular Formula	C₁₈H₁₄N₂O₄
Molecular Weight	322.31
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light brown to brown Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 200-256-5
MDL	MFCD00292551
SMILES	O=C(C1=C(O)C=C2C=CC=CC2=C1)N/N=C/C3=CC=C(O)C(O)=C3
InChIKey	SYNDQCRDGGCQRZ-VXLYETTFSA-N
InChI	InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+
PubChem CID	135533054
Target Point	Dynamin
Passage	Cytoskeleton
Background	Dynasore is a cell-permeable dynamin inhibitor.
Biological Activity	Dynasore是可渗透细胞的发动蛋白抑制剂，IC50为15 μM[1]。
IC50	15μM(GTPase activity of dynamin1 and 2)[1]
Data Literature Source	[1]. Macia E，et al. Dynasore，a cell-permeable inhibitor of dynamin. Dev Cell. 2006 Jun;10(6):839-50. [2]. Mues MB，et al. Dynasore disrupts trafficking of herpes simplex virus proteins. J Virol. 2015 Jul;89(13):6673-84. [3]. Gao D，et al. Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS One. 2013 Apr 15;8(4):e60967. [4]. Li G，et al. Dynasore Improves Motor Function Recovery via Inhibition of Neuronal Apoptosis and Astrocytic Proliferation after Spinal Cord Injury in Rats. Mol Neurobiol. 2016 Nov 7.
Unit	Piece
Specification	10mg 10mM*1mL in DMSO 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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