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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > EX-527CAS：49843-98-3
Molecular Formula：C13H13ClN2O
Molecular Weight：248.71
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 49843-98-3 |
| Name | EX-527 |
| Molecular Formula | C13H13ClN2O |
| Molecular Weight | 248.71 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00142116 |
| SMILES | O=C(C1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N |
| InChIKey | FUZYTVDVLBBXDL-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17) |
| PubChem CID | 5113032 |
| Target Point | Sirtuin（SIRT1） |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Epigenetics |
| Background | EX-527 is a potent and selective SIRT1 inhibitor. |
| Biological Activity | Selisistat (EX-527) 是一种有效，选择性的 SIRT1 抑制剂，IC50 为 98 nM。[1-4] |
| IC50 | SIRT1:98nM;SIRT2:19.6μM;SIRT3:48.7μM [1-4] |
| Data Literature Source | [1]. Solomon JM，et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol. 2006 Jan;26(1):28-38. [2]. Jia Y，et al. SIRT1 is a regulator in high glucose-induced inflammatory response in RAW264.7 cells. PLoS One. 2015 Mar 20;10(3):e0120849. [3]. Wang X，et al. Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice. Obesity (Silver Spring). 2015 Jun;23(6):1209-17. [4]. Napper AD，et al. Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54 |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Jiang X, Wang J. Cancers (Basel). 2020 Feb 20;12(2):493.
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Knockdown of TFAM in Tumor Cells Retarded Autophagic Flux through Regulating p53 Acetylation and PISD Expression
Click to check >>Author：Jiang X; Wang J
IF：6.5750
Publish_to：Cancers (Basel)
PMID：32093281
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