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GLPG0634

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Cat.No：IG1010 Solarbio

CAS：1206161-97-8

Molecular Formula：C₂₁H₂₃N₅O₃S

Molecular Weight：425.5

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1206161-97-8
Name	GLPG0634
Molecular Formula	C₂₁H₂₃N₅O₃S
Molecular Weight	425.5
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD20527867
SMILES	O=C(C1CC1)NC2=NN3C(C4=CC=C(CN5CCS(CC5)(=O)=O)C=C4)=CC=CC3=N2
InChIKey	RIJLVEAXPNLDTC-UHFFFAOYSA-N
InChI	InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
PubChem CID	49831257
Target Point	JAK
Passage	JAK/STAT Signaling
Background	GLPG0634 is a selective JAK inhibitor.
Biological Activity	GLPG0634 是一种选择性的 JAK 抑制剂，能够有效抑制 JAK1，JAK2，JAK3 和 TYK2 的活性，IC50 值分别为 10 nM，28 nM，810 nM 和 116 nM[1-2]。
IC50	JAK1:10nM;JAK2:28nM;JAK3:810nM;Tyk2:116nM [1-2]
Data Literature Source	[1]. Van Rompaey L，et al. Preclinical characterization of GLPG0634，a selective inhibitor of JAK1，for the treatment of inflammatory diseases. J Immunol. 2013，191(7)，3568-3577. [2]. Menet CJ，et al. Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634. J Med Chem. 2014 Nov 17
Unit	Piece
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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