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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > GSK J4 HydrochlorideCAS：1797983-09-5
Molecular Formula：C24H27N5O2·HCl
Molecular Weight：453.96
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1797983-09-5 |
| Name | GSK J4 Hydrochloride |
| Molecular Formula | C24H27N5O2·HCl |
| Molecular Weight | 453.96 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26142638 |
| SMILES | O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1 |
| InChIKey | TYXWLTBYINKVNT-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H27N5O2.ClH/c1-2-31-23(30)10-14-26-21-17-22(28-24(27-21)20-9-5-6-13-25-20)29-15-11-18-7-3-4-8-19(18)12-16-29;/h3-9,13,17H,2,10-12,14-16H2,1H3,(H,26,27,28);1H |
| PubChem CID | 71729974 |
| Target Point | Histone Demethylase |
| Passage | Epigenetics |
| Background | GSK J4 Hydrochloride is a potent dual inhibitor of H3K27me3/me2 demethylases JMJD3/KDM6B and UTX/KDM6A |
| Biological Activity | GSK-J4是一种有效的H3K27me3组蛋白赖氨酸脱甲基酶 (KDM) 抑制剂，抑制 KDM6B和KDM6A的 IC50 分别为8.6 μM 和 6.6 μM[1-6]。 |
| IC50 | 8.6μM(KDM6B)，6.6μM(KDM6A)[5] |
| Data Literature Source | [1]. Kruidenier L，et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8. [2]. Donas C，et al. The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. J Autoimmun. 2016 Dec;75:105-117. [3]. Yapp C，et al. H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis. Arthritis Res Ther. 2016 Jul 7;18(1):158 [4]. Kamikawa YF，et al. Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. PLoS One. 2015 May 20;10(5):e0125626 [5]. Heinemann B，et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2 [6]. Majumder S，et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499. |
| Unit | Piece |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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