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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > GW 501516CAS：317318-70-0
Molecular Formula：C21H18F3NO3S2
Molecular Weight：453.5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 317318-70-0 |
| Name | GW 501516 |
| Molecular Formula | C21H18F3NO3S2 |
| Molecular Weight | 453.5 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD09033000 |
| SMILES | OC(COC1=CC=C(C=C1C)SCC2=C(N=C(S2)C3=CC=C(C=C3)C(F)(F)F)C)=O |
| InChIKey | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27) |
| PubChem CID | 9803963 |
| Target Point | PPAR |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | GW 501516 is an agonist of PPARδ. |
| Biological Activity | GW 501516是 PPARδ 的激动剂，EC50 值为 1.1 nM[1-5]。 |
| IC50 | PPARδ:1.1nM(EC50)[1-5] |
| Data Literature Source | [1]. Wei ZL，et al. A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta. J Org Chem. 2003 Nov 14;68(23):9116-8. [2]. Mosti MP，et al. Effects of the peroxisome proliferator-activated receptor (PPAR)-δ agonist GW 501516 on bone and muscle in ovariectomized rats. Endocrinology. 2014 Jun;155(6):2178-89. [3]. Yang X，et al. GW 501516，a PPARδ agonist，ameliorates tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice. PLoS One. 2011;6(9):e25271. [4]. Chen W，et al. A metabolomic study of the PPARδ agonist GW 501516 for enhancing running endurance in Kunming mice. Sci Rep. 2015 May 6;5:9884. [5]. Ji Y，et al. PPARβ/δ Agonist GW501516 Inhibits Tumorigenicity of Undifferentiated Nasopharyngeal Carcinoma in C666-1 Cells by Promoting Apoptosis. Front Pharmacol. 2018 Jun 28;9:648. |
| Unit | Piece |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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