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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > GW3965 HydrochlorideCAS：405911-17-3
Molecular Formula：C33H31ClF3NO3·HCl
Molecular Weight：618.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 405911-17-3 |
| Name | GW3965 Hydrochloride |
| Molecular Formula | C33H31ClF3NO3·HCl |
| Molecular Weight | 618.51 |
| Solubility | Soluble in DMSO ≥20mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD08276920 |
| SMILES | ClC1=C(C(F)(F)F)C=CC=C1CN(CC(C2=CC=CC=C2)C3=CC=CC=C3)CCCOC4=CC(CC(O)=O)=CC=C4.[H]Cl |
| InChIKey | NMPUWJFHNOUNQU-UHFFFAOYSA-N |
| InChI | InChI=1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H |
| PubChem CID | 16078973 |
| Target Point | LXR |
| Passage | Metabolic Enzyme&Protease |
| Background | GW3965 HCl is a potent and selective LXR agonist. |
| Biological Activity | GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ， respectively.[1-4] |
| IC50 | EC50: 190 nM (hLXRα)， 30 nM (hLXRβ)[4] |
| Data Literature Source | [1]. Mitro， Nico.， et al. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals. Neurochemistry International (2012)， 60(6)， 616-621. [2]. Guo， Deliang.， et al. An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway. Cancer Discovery (2011)， 1(5)， 442-456. [3]. Spyridon， Michael.， et al. LXR as a novel antithrombotic target. Blood (2011)， 117(21)， 5751-5761. [4]. Collins JL， et al. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem. 2002 May 9;45(10):1963-6. |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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