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I-BET151

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Cat.No：II0600 Solarbio

CAS：1300031-49-5

Molecular Formula：C₂₃H₂₁N₅O₃

Molecular Weight：415.44

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to brown Solid

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Product Information

CAS	1300031-49-5
Name	I-BET151
Molecular Formula	C₂₃H₂₁N₅O₃
Molecular Weight	415.44
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD22124472
SMILES	C[C@@H](N1C(C(C=C(OC)C(C2=C(C)ON=C2C)=C3)=C3N=C4)=C4NC1=O)C5=CC=CC=N5
InChIKey	VUVUVNZRUGEAHB-CYBMUJFWSA-N
InChI	InChI=1S/C23H21N5O3/c1-12-21(14(3)31-27-12)16-9-18-15(10-20(16)30-4)22-19(11-25-18)26-23(29)28(22)13(2)17-7-5-6-8-24-17/h5-11,13H,1-4H3,(H,26,29)/t13-/m1/s1
PubChem CID	52912189
Target Point	Epigenetic Reader Domain
Passage	Epigenetics
Background	Hypoxanthine is a purine derivative.
Biological Activity	I-BET151 是一种BET bromodomain抑制剂，抑制 BRD4，BRD2 和 BRD3 的 pIC50 分别为 6.1，6.3 和 6.6。[1-2]
Data Literature Source	[1]. Seal J，et al. Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A). Bioorg Med Chem Lett. 2012 Apr 15;22(8):2968-72. [2]. Chaidos A，et al. Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762. Blood. 2014 Jan 30;123(5):697-705
Unit	Piece
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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