Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > INT-767

INT-767

Manual Download

Cat.No：II0630 Solarbio

CAS：1000403-03-1

Molecular Formula：C₂₅H₄₃NaO₆S

Molecular Weight：494.66

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	1000403-03-1
Name	INT-767
Molecular Formula	C₂₅H₄₃NaO₆S
Molecular Weight	494.66
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	C[C@H](CCOS(=O)([O-])=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
InChIKey	TXIWHUPIUUZFFK-PMWRKVJASA-M
InChI	InChI=1S/C25H44O6S.Na/c1-5-17-21-14-16(26)8-11-25(21,4)20-9-12-24(3)18(6-7-19(24)22(20)23(17)27)15(2)10-13-31-32(28,29)30;/h15-23,26-27H,5-14H2,1-4H3,(H,28,29,30);/q;+1/p-1/t15-,16-,17-,18-,19+,20+,21+,22+,23-,24-,25-;/m1./s1
PubChem CID	23712772
Target Point	FXR
Passage	Metabolic Enzyme&Protease
Background	INT-767 is a G-protein coupled/Farnesoid X-activated receptor agonist
Biological Activity	INT-767是法尼醇X受体/TGR5双激动剂，平均 EC50 分别为30和630 nM。INT-767 是一种安全有效的 FXR 和 TGR5 依赖性途径的调节剂。[1-2]
Data Literature Source	[1]. Baghdasaryan A，et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. [2]. Rizzo G，et al. Functional characterization of the semisynthetic bile acid derivative INT-767，a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.
Unit	Piece
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.