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mLN 4924

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Cat.No：IM1030 Solarbio

CAS：905579-51-3

Molecular Formula：C₂₁H₂₅N₅O₄S

Molecular Weight：443.52

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	905579-51-3
Name	mLN 4924
Molecular Formula	C₂₁H₂₅N₅O₄S
Molecular Weight	443.52
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00006838
SMILES	O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@H]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O
InChIKey	MPUQHZXIXSTTDU-QXGSTGNESA-N
InChI	InChI=1S/C21H25N5O4S/c22-31(28,29)30-11-14-9-15(10-19(14)27)26-8-7-17-20(23-12-24-21(17)26)25-18-6-5-13-3-1-2-4-16(13)18/h1-4,7-8,12,14-15,18-19,27H,5-6,9-11H2,(H2,22,28,29)(H,23,24,25)/t14-,15+,18-,19-/m0/s1
PubChem CID	16720766
Target Point	NAE
Passage	Ubiquitin
Background	mLN4924 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor.
Biological Activity	MLN4924 是一种有效，选择性的NEDD8 活化酶 (NAE) 抑制剂，IC50 为 4.7 nM[1]。
IC50	4.7nM(NAE)[1]
Data Literature Source	[1]. Soucy TA，et al. An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. Nature. 2009 Apr 9;458(7239):732-6. [2]. F S Wolenski，et al. The NAE inhibitor pevonedistat (MLN4924) synergizes with TNF-α to activate apoptosis. Cell Death Discovery 1，Article number: 15034 (2015)
Unit	Piece
Specification	5mg 10mM*1mL in DMSO

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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