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My CartCAS：1315355-93-1
Molecular Formula：C29H30F3N5O2
Molecular Weight：537.58
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1315355-93-1 |
| Name | NG25 |
| Molecular Formula | C29H30F3N5O2 |
| Molecular Weight | 537.58 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD19443255 |
| SMILES | O=C(NC1=CC(C(F)(F)F)=C(CN(CC2)CCN2CC)C=C1)C3=CC(OC4=C5C(NC=C5)=NC=C4)=C(C)C=C3 |
| Target Point | MAP4K |
| Passage | MAPK |
| Background | NG25 is a dual inhibitor of TAK1 and MAP4K2. |
| Biological Activity | NG25 是一种 TAK1 和 MAP4K2 的双抑制剂，IC50 值分别为 149 nM 和 21.7 nM[1-3]。 |
| IC50 | TAK1:149nM;mAP4K2:21.7nM [1-3] |
| Data Literature Source | [1]. Tan L，et al. Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem. 2015 Jan 8;58(1):183-96. [2]. Pauls E，et al. Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells. J Biol Chem. 2012 Jun 1;287(23):19216-28. [3]. Wang Z，et al. TAK1 inhibitor NG25 enhances doxorubicin-mediated apoptosis in breast cancer cells. Sci Rep. 2016 Sep 7;6:32737 |
| Unit | Piece |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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