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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > PF-562271 BesylateCAS：939791-38-5
Molecular Formula：C27H26F3N7O6S2
Molecular Weight：665.66
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 939791-38-5 |
| Name | PF-562271 Besylate |
| Molecular Formula | C27H26F3N7O6S2 |
| Molecular Weight | 665.66 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00011686 |
| SMILES | CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(NC(C4)=O)C=C3)=NC=C2C(F)(F)F)=O.O=S(C5=CC=CC=C5)(O)=O |
| Target Point | FAK;PYK2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | PF-562271 besylate is a potent, ATP-competitive, and reversible inhibitor of FAK and Pyk2 kinase. |
| Biological Activity | PF-562271 besylate 是一种有效的, ATP 竞争性的, 可逆的 FAK 和 Pyk2 kinase 抑制剂, IC50 值分别为 1.5 nM 和 13 nM, 对其活性是对CDK酶以外的其他酶的 100 多倍[1-3]。 |
| IC50 | IC50: 1.5nM (FAK) ， 13nM (Pyk2) [1-3] |
| Data Literature Source | [1]. Roberts WG， et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor， PF-562，271. Cancer Res， 2008， 68 (6) ， 1935-1944. [2]. Lim ST， et al. FERM control of FAK function: implications for cancer therapy. Cell Cycle， 2008， 7 (15) ， 2306-2314. [3]. Canel M， et al. Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res， 2010， 70 (22) ， 9413-9422. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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