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My CartCAS：931398-72-0
Molecular Formula：C19H16N2O5
Molecular Weight：352.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 931398-72-0 |
| Name | IOX2 |
| Molecular Formula | C19H16N2O5 |
| Molecular Weight | 352.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 804-733-4 |
| MDL | MFCD22580424 |
| SMILES | O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O |
| Target Point | HIF/HIF Prolyl-Hydroxylase |
| Passage | HIF |
| Background | IOX2 is a specific prolyl hydroxylase-2 (PHD2) inhibitor. |
| Biological Activity | IOX2 是一种特异性的脯氨酰羟化酶-2 (PHD2) 抑制剂，IC50 为 22 nM。[1-2] |
| IC50 | 22nM(PHD2)[1] |
| Data Literature Source | [1]. Chowdhury R，et al. Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. ACS Chem Biol. 2013 Jul 19;8(7):1488-96. [2]. Deppe J，et al. Impairment of hypoxia-induced HIF-1α signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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