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BGJ398

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Cat.No：IB1110 Solarbio

CAS：872511-34-7

Molecular Formula：C₂₆H₃₁Cl₂N₇O₃

Molecular Weight：560.48

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	872511-34-7
Name	BGJ398
Molecular Formula	C₂₆H₃₁Cl₂N₇O₃
Molecular Weight	560.48
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD22123241
SMILES	ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O
Target Point	FGFR
Passage	Angiogenesis; Protein Tyrosine Kinase/RTK
Background	It is a potent inhibitor of the FGFR family.
Biological Activity	BGJ-398是 FGFR 家族的有效抑制剂，抑制 FGFR1，FGFR2，FGFR3 和 FGFR4 的 IC50 分别为0.9 nM，1.4 nM，1 nM，60 nM。[1-3]
IC50	0.9nM(FGFR1);1.4nM(FGFR2);1nM(FGFR3);60nM(FGFR4)[1-3]
Data Literature Source	[1]. Guagnano V，et al. Discovery of 3-(2，6-Dichloro-3，5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-me thyl-urea (NVP-BGJ398)，A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor T [2]. Konecny GE，et al. Activity of the fibroblast growth factor receptor inhibitors dovitinib (TKI258) and NVP-BGJ398 in human endometrial cancer cells. Mol Cancer Ther. 2013 May;12(5):632-42. [3]. Liu H，et al. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discov. 2018 Mar;8(3):354-369.
Unit	Bottle
Specification	5mg 10mg 20mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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