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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > TAE-226CAS：761437-28-9
Molecular Formula：C23H25ClN6O3
Molecular Weight：468.94
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 761437-28-9 |
| Name | TAE-226 |
| Molecular Formula | C23H25ClN6O3 |
| Molecular Weight | 468.94 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD12031516 |
| SMILES | O=C(C1=C(C=CC=C1)NC2=NC(NC3=C(C=C(C=C3)N4CCOCC4)OC)=NC=C2Cl)NC |
| Target Point | FAK;IGF-1R;Insulin Receptor;PYK2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | NVP-TAE 226 is a dual tyrosine kinase inhibitor. |
| Biological Activity | TAE-226 是一种双重酪氨酸激酶抑制剂，作用于 FAK 和 IGF-IR，IC50 分别为 5.5 nM 和 0.14 μM[1-2]。 |
| IC50 | 5.5nM(FAK);3.5nM(Pyk2);0.14μM(IGF-IR);0.16μM(c-Met);0.36μM(KDR);0.48μM(Flt3)[1-2] |
| Data Literature Source | [1]. Liu TJ，et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo. Mol Cancer Ther，2007，6(4)，1357-1367. [2]. Delimont D，et al. Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One. 2014 Jun 10;9(6):e99083 |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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