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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > PF-562271CAS：717907-75-0
Molecular Formula：C21H20F3N7O3S
Molecular Weight：507.49
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 717907-75-0 |
| Name | PF-562271 |
| Molecular Formula | C21H20F3N7O3S |
| Molecular Weight | 507.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038299 |
| SMILES | CS(=O)(N(C)C1=NC=CC=C1CNC2=NC(NC3=CC4=C(C=C3)NC(C4)=O)=NC=C2C(F)(F)F)=O |
| Target Point | FAK; PYK2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | PF-562271 is a potent, reversible, ATP-competitive FAK and Pyk2 kinase inhibitor. |
| Biological Activity | PF-562271 是有效，可逆，ATP竞争性的 FAK 和 Pyk2 激酶抑制剂，IC50 分别为 1.5 和 13 nM。[1-3] |
| IC50 | 1.5nM(FAK)，13nM(Pyk2)，30nM(CDK2)，47nM(CDK3)，58nM(CDK1)，97nM(CDK7)，97nM(Flt3)[1-3] |
| Data Literature Source | [1]. Roberts WG，et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor，PF-562，271. Cancer Res，2008，68(6)，1935-1944. [2]. Crompton BD，et al. High-throughput tyrosine kinase activity profiling identifies FAK as a candidate therapeutic target in Ewing sarcoma. Cancer Res. 2013 May 1;73(9):2873-83. [3]. Bagi CM，et al. Dual focal adhesion kinase/Pyk2 inhibitor has positive effects on bone tumors: implications for bone metastases. Cancer. 2008 May 15;112(10):2313-21. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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