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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Y15CAS：4506-66-5
Molecular Formula：C6H10N4·4HCl
Molecular Weight：284.01
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 4506-66-5 |
| Name | Y15 |
| Molecular Formula | C6H10N4·4HCl |
| Molecular Weight | 284.01 |
| Solubility | Soluble in Water |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 224-822-6 |
| MDL | MFCD00012970 |
| SMILES | [H]Cl.[H]Cl.[H]Cl.[H]Cl.NC1=CC(N)=C(N)C=C1N |
| Target Point | FAK |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Y15 specifically inhibits FAK autophosphorylation. |
| Biological Activity | Y15 特异性抑制 FAK 自磷酸化。[1-3] |
| Data Literature Source | [1]. Hochwald SN，et al. A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle. 2009 Aug;8(15):2435-43. [2]. O'Brien S，et al. FAK inhibition with small molecule inhibitor Y15 decreases viability，clonogenicity，and cell attachment in thyroid cancer cell lines and synergizes with targeted therapeutics. Oncotarget. 2014 Sep 15;5(17):7945-59. [3]. Zheng D，et al. A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts. Mol Carcinog. 2010 Feb;49(2):200-9. |
| Unit | Bottle |
| Specification | 10mg 10mM*1mL in DMSO 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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