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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > TasquinimodCAS：254964-60-8
Molecular Formula：C20H17F3N2O4
Molecular Weight：406.36
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 254964-60-8 |
| Name | Tasquinimod |
| Molecular Formula | C20H17F3N2O4 |
| Molecular Weight | 406.36 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18251454 |
| SMILES | O=C(C1=C(O)C2=C(N(C)C1=O)C=CC=C2OC)N(C)C3=CC=C(C(F)(F)F)C=C3 |
| Target Point | HDAC |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Tasquinimod is an antiangiogenic agent. |
| Biological Activity | Tasquinimod是一种抗血管生成剂。Tasquinimod与HDAC4和S100A9在癌症和浸润宿主细胞中的高亲和力结合，在受损的肿瘤微环境中抑制血管生成反应所需的适应性生存途径。 Tasquinimod与 HDAC4 Zn2+ 结合结构域结合的Kd 值为10-30 nM。Tasquinimod抑制缺氧诱导的组蛋白乙酰化降低而不降低HDAC表达或直接抑制HDAC活性。[1-3] |
| Data Literature Source | [1]. Isaacs JT，et al. Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment. Cancer Res. 2013 Feb 15;73(4):1386-99. [2]. Isaacs JT，et al. Anti-cancer potency of tasquinimod is enhanced via albumin-binding facilitating increased uptake in the tumor microenvironment. Oncotarget. 2014 Sep 30;5(18):8093-106. [3]. Olsson A，et al. Tasquinimod (ABR-215050)，a quinoline-3-carboxamide anti-angiogenic agent，modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010 May 17;9:107 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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