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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > LFM-A13CAS：244240-24-2
Molecular Formula：C11H8Br2N2O2
Molecular Weight：360
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 244240-24-2 |
| Name | LFM-A13 |
| Molecular Formula | C11H8Br2N2O2 |
| Molecular Weight | 360 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | BrC1=C(NC(/C(C#N)=C(C)\O)=O)C=C(Br)C=C1 |
| Target Point | Btk |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | LFM-A13 is a potent BTK, JAK2, PLK inhibitor. |
| Biological Activity | LFM-A13 是一种有效的 BTK，JAK2，PLK 抑制剂，可抑制 BTK，Plx1 和 PLK3 的活性，IC50 分别为 2.5 μM，10 μM 和 61 μM。[1-4] |
| Data Literature Source | [1]. Mahajan S，et al. Rational design and synthesis of a novel anti-leukemic agent targeting Bruton's tyrosine kinase (BTK)，LFM-A13 [alpha-cyano-beta-hydroxy-beta-methyl-N-(2，5-dibromophenyl)propenamide]. J Biol Chem. 1999 Apr 2;274(14):9587-99. [2]. van den Akker E，et al. The Btk inhibitor LFM-A13 is a potent inhibitor of Jak2 kinase activity. Biol Chem. 2004 May;385(5):409-13. [3]. 'Sahin K，et al. LFM-A13，a potent inhibitor of polo-like kinase，inhibits breast carcinogenesis by suppressing proliferation activity and inducing apoptosis in breast tumors of mice. Invest New Drugs. 2017 Nov 15.' [4]. Uckun FM，et al. Anti-breast cancer activity of LFM-A13，a potent inhibitor of Polo-like kinase (PLK). Bioorg Med Chem. 2007 Jan 15;15(2):800-14. Epub 2006 Oct 26. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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