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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > ARQ-531CAS：2095393-15-8
Molecular Formula：C25H23ClN4O4
Molecular Weight：478.93
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2095393-15-8 |
| Name | ARQ-531 |
| Molecular Formula | C25H23ClN4O4 |
| Molecular Weight | 478.93 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31692379 |
| SMILES | O=C(C1=C(C=C(OC2=CC=CC=C2)C=C1)Cl)C3=CNC4=NC=NC(N[C@@H]5CC[C@@H](CO)OC5)=C34 |
| Target Point | Btk |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | ARQ 531 is an ATP-competitive tyrosine kinase inhibitor targeting BTK. |
| Biological Activity | Nemtabrutinib (ARQ 531, MK-1026) 是一种ATP竞争性的酪氨酸激酶抑制剂，靶向BTK，IC50为0.85 nM。它具有明显的激酶选择性，对几种关键的致瘤因子（如TEC、Trk和Src中的一些家族成员）具有强抑制活性。[1-3] |
| Data Literature Source | [1] Sudharshan Eathiraj，et al. EHA Congress. 2017，ePoster number: E1400. [2] Sudharshan Eathiraj，et al. AACR Cancer Res 2018. 78(13 Suppl):Abstract nr 1963. [3] Sean D. Reiff，et al. Blood. 2016，128:3232. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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