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ENMD-2076 Tartrate

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Cat.No：IE0840 Solarbio

CAS：1291074-87-7

Molecular Formula：C₂₅H₃₁N₇O₆

Molecular Weight：525.56

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light brown to brown Solid

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Product Information

CAS	1291074-87-7
Name	ENMD-2076 Tartrate
Molecular Formula	C₂₅H₃₁N₇O₆
Molecular Weight	525.56
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light brown to brown Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18633211
SMILES	O[C@H](C(O)=O)[C@@H](C(O)=O)O.CC1=CC(NC2=NC(/C=C/C3=CC=CC=C3)=NC(N4CCN(CC4)C)=C2)=NN1
Target Point	FLT3;Src;VEGFR3/FLT4;Aurora Kinase;RET
Passage	Angiogenesis; Protein Tyrosine Kinase/RTK;Cell Cycle
Background	ENMD-2076 Tartrate is a multi-targeted kinase inhibitor.
Biological Activity	ENMD-2076 Tartrate 是多靶点激酶抑制剂，抑制 Aurora A，Flt3，KDR/VEGFR2，Flt4/VEGFR3，FGFR1，FGFR2，Src，PDGFRα 的IC50 值分别为1.86，14，58.2，15.9，92.7，70.8，20.2 and 56.4 nM[1-2]。
Data Literature Source	[1]. Fletcher GC，et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37. [2]. Wang X，et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor，ENMD-2076，against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25.
Unit	Bottle
Specification	5mg 10mg 25mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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