| English Name |
Anti-EGFRvII Polyclonal Antibody |
| Chinese Name |
表皮生长因子受体抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Dilution Ratio |
WB 1:500-2000. ELISA 1:5000-10000. IHC 1:100-500. FCM 3μg/Test. ICC 1:100. IF 1:100-500. |
| Target |
EGFRvII |
| Synonyms |
EGFR, Avian erythroblastic leukemia viral (v erb b) oncogene homolog, Avian erythroblastic leukemia viral (verbb) oncogene homolog, Cell growth inhibiting protein 40, Cell proliferation inducing protein 61, EGF R, EGFR, Epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog), Epidermal growth factor receptor (erythroblastic leukemia viral (v erb b) oncogene homolog avian), Epidermal growth factor receptor, erbb 1, Erbb, Erbb1, HER1, mENA, Oncogene ERBB, PIG61, Receptor tyrosine protein kinase ErbB 1, Receptor tyrosine protein kinase ErbB1, Urogastrone, wa2, Wa5, EGFR_HUMAN |
| Background |
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. |
| Swiss Prot |
P00533 |
| Gene ID |
1956 |
| Subcellular Location |
Nucleus Endosome Plasma membrane Golgi apparatus Endoplasmic reticulum secreted |
| Immunogen |
A synthetic peptide of human EGFRvII |
| Public Immunogen Range |
11-120/1081aa |
| Calculated MW |
134/45/77/69kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol. |
| Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Human |
| Application |
ELISA FCM IF ICC IHC WB |
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