| English Name |
Anti-MAP1LC3B Polyclonal Antibody |
| Chinese Name |
微管相关蛋白1轻链3β抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Predicted Reactivity |
Chicken;Dog;Pig;Cow;Horse |
| Dilution Ratio |
ELISA 1:5000-10000. IHC 1:100-500. IF 1:100-500. |
| Target |
MAP1LC3B |
| Synonyms |
Microtubule-associated protein 1 light chain 3 beta,ATG8F, Autophagy related protein LC3 B, Autophagy related ubiquitin like modifier LC3 B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3 like protein 2, MAP1 light chain 3-like protein 2, MAP1A/1B light chain 3 B, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B, MAP1ALC3, MAP1LC3B, Microtubule associated protein 1 light chain 3 beta, Microtubule associated proteins 1A/1B light chain 3B, Microtubule-associated protein 1 light chain 3 beta, Microtubule-associated proteins 1A/1B light chain 3B, MLP3B_HUMAN |
| Background |
A major contributor to cellular homeostasis is the ability of the cell to strike a balance between the formation and degradation/removal of its cellular components. This process of internal cellular turn-over is called autophagy (self-eating), and is facilitated by a pathway of around 16 interacting proteins in the human. LC3, a ubiquitin-like modifier protein, is the human homolog of yeast Apg8 and is involved in the formation of autophagosomal vacuoles, called autophagosomes. LC3 is expressed as 3 splice variants (LC3A, LC3B and LC3C), which exhibit different tissue distributions and are processed into cytosolic and autophagosomal membrane-bound forms, termed LC3-I and LC3-II, respectively. A disruption to the autophagic process is now associated with the progression of several cancers, neurodegenerative disorders and cardiac pathologies, where LC3 is widely employed as a marker for autophagy. |
| Swiss Prot |
Q9GZQ8 |
| Gene ID |
81631 |
| Subcellular Location |
Cytoplasm Cytoplasmic vesicle Endomembrane system Lipid-anchor autophagosome autophagosome membrane cytoskeleton |
| Immunogen |
A synthetic peptide of human MAP1LC3B |
| Public Immunogen Range |
21-121/121aa |
| Calculated MW |
15kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
0.01M TBS(pH7.4) with 1% BSA，0.03% Proclin300 and 50% Glycerol. |
| Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Rabbit Rat Mouse Human |
| Application |
ELISA IF IHC |
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