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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > Bleomycin Sulfate (mixture)CAS：9041-93-4/11056-06-7
Molecular Formula：A2:C55H85N17O25S4;B2:C55H84N20O21S2
Molecular Weight：A2:1512.62;B2:1425.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Appearance：White to yellow Solid
Qty：
Size：
| CAS | 9041-93-4/11056-06-7 |
| Name | Bleomycin Sulfate (mixture) |
| Molecular Formula | A2:C55H85N17O25S4;B2:C55H84N20O21S2 |
| Molecular Weight | A2:1512.62;B2:1425.51 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Enzyme Activity/Titer | 1.5-2.0U/mg |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00070310 |
| SMILES | CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O |
| InChIKey | OYVAGSVQBOHSSS-WXFSZRTFSA-O |
| InChI | InChI=1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14，17-19，21-25，29-30，34-43，53-54，64，73-75，77-81H，7-13，15-16，56H2，1-6H3，(H13-，57，58，59，60，61，62，63，65，66，69，70，71，72，76，82，83，84，85，86，87，88)/p+1/t21-，22+，23+，24-，25-，29?，30?，34-，35-，36-，37?，38?，39?，40?，41-，42?，43?，53?，54?/m0/s1 |
| PubChem CID | 5360373 |
| Target Point | DNA/RNA Synthesis |
| Passage | Cell Cycle;DNA Damage/DNA Repair |
| Background | It is a class of water-Soluble alkaline glycopeptide antibiotics. It mainly inhibits the incorporation of thymidine into DNA, combines with DNA to destroy and decompose it, and acts on the S phase of the proliferating cell cycle. Can be used for resistance screening and induction of pulmonary fibrosis models. |
| Biological Activity | Bleomycin sulfate是具有有效抗肿瘤活性的DNA合成抑制剂。博莱霉素（BLM）被选为人淋巴细胞中研究最好的微核（MN）诱导剂，具有不同的遗传毒性机制。最常见的博来霉素诱导的DNA损伤是单链和双链断裂和单个apuinic / apyrimidinic位点。同时博来霉素是真正的放射性模拟化合物，几乎完全类似于电离辐射的遗传效应。[1-4] |
| Data Literature Source | [1]. Hovhannisyan G，et al. Comparative analysis of individual chromosome involvement in micronuclei induced by mitomycin C and bleomycin in human leukocytes. Mol Cytogenet. 2016 Jun 21;9:49. [2]. Jaaskela-Saari HA，et al. Squamous cell cancer cell lines: sensitivity to bleomycin and suitability for animal xenograft studies. Acta Otolaryngol Suppl. 1997;529:241-4. [3]. Paviolo NS，et al. Telomere instability is present in the progeny of mammalian cells exposed to bleomycin. Mutat Res. 2012 Jun 1;734(1-2):5-11. [4]. Shi K，et al. Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-β，Smad3 and JAK-STAT pathway. Int J Clin Exp Med. 2014 Sep 15;7(9):2645-50. |
| Unit | Bottle |
| Specification | 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Mix
Yang S, et al. Evid Based Complement Alternat Med. 2020 Sep 8;2020:7483278. control group (control), bleomycin group (model), bleomycin + prednisone acetate group (positive), and bleomycin + Bufei decoction (treatment).
Yang S, et al. Evid Based Complement Alternat Med. 2020 Sep 8;2020:7483278. control group (control), bleomycin group (model), bleomycin + prednisone acetate group (positive), and bleomycin + Bufei decoction (treatment).
Yang S, et al. Evid Based Complement Alternat Med. 2020 Sep 8;2020:7483278. control group (control), bleomycin group (model), bleomycin + prednisone acetate group (positive), and bleomycin + Bufei decoction (treatment).
Yang S, et al. Evid Based Complement Alternat Med. 2020 Sep 8;2020:7483278. control group (control), bleomycin group (model), bleomycin + prednisone acetate group (positive), and bleomycin + Bufei decoction (treatment).
Yang S, et al. Evid Based Complement Alternat Med. 2020 Sep 8;2020:7483278. control group (control), bleomycin group (model), bleomycin + prednisone acetate group (positive), and bleomycin + Bufei decoction (treatment).
来源文献：Yang S, et al. Evid Based Complement Alternat Med. 2020 Sep 8;2020:7483278. control group (control), bleomycin group (model), bleomycin + prednisone acetate group (positive), and bleomycin + Bufei decoction (treatment).
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Human Endometrial Regenerative Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis in Mice
Click to check >>Author：Zhao Y. Lan X. Wang Y. Xu X. Lu S. Li X. Zhang B.
IF：4.7200
Publish_to：Stem Cells Int.
PMID：30147727
Bufei Decoction Alleviated Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Mice by Anti-Inflammation
Click to check >>Author：Yang S; Cui W; Wang M; Xing L; Wang Y; Zhu P; Qu Q
IF：2.4000
Publish_to：Evid Based Complement Alternat Med
PMID：32963571
Determination of steroid hydroxylation specificity of an industrial strain Aspergillus ochraceus TCCC41060 by cytochrome P450 gene CYP68J5
Click to check >>Author：Wang X . Yang X . Jia X
IF：2.1250
Publish_to：Annals of Microbiology
PMID：
Bufei Decoction Alleviated Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Mice by Anti-Inflammation
Click to check >>Author：Shanjun Yang 1, Wenwen Cui 2, Mingye Wang 2, Lumin
IF：0.0000
Publish_to：Evid Based Complement Alternat Med
PMID：32963571
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