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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > BrigatinibCAS：1197953-54-0
Molecular Formula：C29H39ClN7O2P
Molecular Weight：584.09
Storage：Powder:-20℃，2 years
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1197953-54-0 |
| Name | Brigatinib |
| Molecular Formula | C29H39ClN7O2P |
| Molecular Weight | 584.09 |
| Solubility | Soluble in DMSO ≥0.1mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years |
| EC | EINECS 1592732-453-0 |
| MDL | MFCD29472221 |
| SMILES | CN1CCN(CC1)C2CCN(CC2)C3=CC(=C(C=C3)NC4=NC=C(C(=N4)NC5=CC=CC=C5P(=O)(C)C)Cl)OC |
| InChIKey | AILRADAXUVEEIR-UHFFFAOYSA-N |
| InChI | InChI=1S/C29H39ClN7O2P/c1-35-15-17-37(18-16-35)21-11-13-36(14-12-21)22-9-10-24(26(19-22)39-2)33-29-31-20-23(30)28(34-29)32-25-7-5-6-8-27(25)40(3,4)38/h5-10,19-21H,11-18H2,1-4H3,(H2,31,32,33,34) |
| PubChem CID | 68165256 |
| Target Point | ALK;EGFR;FLT3;IGF-1R;ROS1 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | It is a potent and selective ALK inhibitor. |
| Biological Activity | Brigatinib 是有效，选择性的 ALK 抑制剂，IC50 值为 0.6 nM。[1-3] |
| IC50 | 0.6nM(ALK)[1] |
| Data Literature Source | [1]. Zhang S，et al. The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models. Clin Cancer Res. 2016 Nov 15;22(22):5527-5538 [2]. Huang WS，et al. Discovery of Brigatinib (AP26113)，a Phosphine Oxide-Containing，Potent，Orally Active Inhibitor of Anaplastic Lymphoma Kinase. J Med Chem. 2016 May 26;59(10):4948-64. [3]. Siaw JT，et al. Brigatinib，an anaplastic lymphoma kinase inhibitor，abrogates activity and growth in ALK-positive neuroblastoma cells，Drosophila and mice. Oncotarget. 2016 May 17;7(20):29011-22 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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