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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > Fostamatinib DisodiumCAS：1025687-58-4
Molecular Formula：C23H24FN6Na2O9P
Molecular Weight：624.42
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1025687-58-4 |
| Name | Fostamatinib Disodium |
| Molecular Formula | C23H24FN6Na2O9P |
| Molecular Weight | 624.42 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD15146370 |
| SMILES | CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+] |
| Target Point | Syk |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | Fostamatinib Disodium is a Syk inhibitor. |
| Biological Activity | Fostamatinib Disodium (R788 Disodium) 是活性代谢物R406的原药，是Syk抑制剂，IC50为41 nM。[1-3] |
| Data Literature Source | [1]. Braselmann，S.，et al.，R406，an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther，2006. 319(3): p. 998-1008. [2]. Chen，L.，et al.，SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma. Blood，2008. 111(4): p. 2230-7. [3]. Suljagic，M.，et al.，The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Emu- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling. Blood，2010. 116(23): p. 4894-905. |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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