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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > KW-2449CAS：1000669-72-6
Molecular Formula：C20H20N4O
Molecular Weight：332.4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 1000669-72-6 |
| Name | KW-2449 |
| Molecular Formula | C20H20N4O |
| Molecular Weight | 332.4 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1CN(CCN1)C(=O)C2=CC=C(C=C2)/C=C/C3=NNC4=CC=CC=C43 |
| Target Point | Abl;FGFR1;FLT3 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | KW-2449 is a multi-targeted inhibitor that effectively acts on Flt3. |
| Biological Activity | KW-2449是多靶点激酶抑制剂，对FLT3，ABL，ABLT315I和 Aurora kinase 的 IC50 值分别为6.6，14，4 和 48 nM.[1] |
| Data Literature Source | [1]. Shiotsu Y，et al. KW-2449，a novel multikinase inhibitor，suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood. 2009 Aug 20;114(8):1607-17. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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