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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > HIF > VadadustatCAS：1000025-07-9
Molecular Formula：C14H11ClN2O4
Molecular Weight：306.7
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1000025-07-9 |
| Name | Vadadustat |
| Molecular Formula | C14H11ClN2O4 |
| Molecular Weight | 306.7 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O |
| Target Point | HIF/HIF Prolyl-Hydroxylase |
| Passage | HIF |
| Background | Vadadustat is a novel HIF-PH inhibitor. |
| Biological Activity | Vadadustat是一种新型的可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂，目前开发用于治疗贫血。[1-2] |
| Data Literature Source | [1]. Pergola PE，et al. Vadadustat，a novel oral HIF stabilizer，provides effective anemia treatment in nondialysis-dependent chronic kidney disease. Kidney Int. 2016 Nov;90(5):1115-1122. [2]. Gupta N，et al. Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors: A Potential New Treatment for Anemia in Patients With CKD. Am J Kidney Dis. 2017 Feb 24. pii: S0272-6386(17)30110-5. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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