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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > GDC-0152CAS：873652-48-3
Molecular Formula：C25H34N6O3S
Molecular Weight：498.64
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 873652-48-3 |
| Name | GDC-0152 |
| Molecular Formula | C25H34N6O3S |
| Molecular Weight | 498.64 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26142660 |
| SMILES | C[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC |
| Target Point | IAP |
| Passage | Apoptosis |
| Background | GDC-0152 is a potent XIAP-BIR3, mL-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 antagonist. |
| Biological Activity | GDC-0152 是一种有效的 IAPs 抑制剂，能够分别与 XIAP BIR3 结合域，ML-IAP 的 BIR 结合域，cIAP1 和 cIAP2 的 BIR3 结合域结合，Ki 值分别为 28，14，17 和 43 nM。[1] |
| Data Literature Source | [1]. Flygare JA，et al. Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152). J Med Chem. 2012 May 10;55(9):4101-13 |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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