English Name |
Anti-RAB3A Polyclonal Antibody |
Chinese Name |
RAB3A,RAS致癌基因家族成员抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
IHC 1:100-300. |
Target |
RAB3A |
Synonyms |
RAB3A,RAB3,RAB3A member RAS oncogene family,RAB3B,RAB3B member RAS oncogene family,RAB3C,RAB3C member RAS oncogene family,RAB3D member RAS oncogene family,RAD3D,Ras related protein Rab 3A,Ras related protein Rab 3B,Ras related protein Rab 3C,Ras related protein Rab 3D,D2 2,Glioblastoma overexpressed,GOV,RAB16 |
Background |
Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays also a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. |
Swiss Prot |
P20336 |
Gene ID |
5864 |
Subcellular Location |
Cytoplasm Cell membrane |
Immunogen |
Recombinant protein of human RAB3A |
Public Immunogen Range |
1-220aa |
Calculated MW |
25kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human Rat Mouse |
Application |
IHC |