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Bosentan Monohydrate

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Cat.No：IB1940 Solarbio

CAS：157212-55-0

Molecular Formula：C₂₇H₂₉N₅O₆S·H₂O

Molecular Weight：569.63

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	157212-55-0
Name	Bosentan Monohydrate
Molecular Formula	C₂₇H₂₉N₅O₆S·H₂O
Molecular Weight	569.63
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 1592732-453-0
MDL	MFCD09751188
SMILES	O=S(NC1=NC(C2=NC=CC=N2)=NC(OCCO)=C1OC3=CC=CC=C3OC)(C4=CC=C(C(C)(C)C)C=C4)=O.O
Target Point	Endothelin Receptor
Passage	GPCR & G Protein
Background	Bosentan hydrate is a competitive endothelin-1 (ET) antagonist.
Biological Activity	Bosentan hydrate 是一种竞争性的 endothelin-1 (ET) 拮抗剂，在人SMC中，作用于 ETA 和 ETB 受体，Ki 分别为 4.7 nM 和 95 nM。[1-3]
Data Literature Source	[1]. Dhillon S，et al. Bosentan: a review of its use in the management of mildly symptomatic pulmonary arterial hypertension. Am J Cardiovasc Drugs. 2009;9(5):331-50. [2]. Akamata K，et al. Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1. Arthritis Res Ther. 2014 Apr 3;16(2):R86. [3]. Iglarz M，et al. Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension. Life Sci. 2014 Nov 24;118(2):333-9
Unit	Bottle
Specification	50mg 10mM*1mL in DMSO 100mg 250mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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