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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > BelnacasanCAS：273404-37-8
Molecular Formula：C24H33ClN4O6
Molecular Weight：509
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 273404-37-8 |
| Name | Belnacasan |
| Molecular Formula | C24H33ClN4O6 |
| Molecular Weight | 509 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD23102811 |
| SMILES | ClC1=C(N)C=CC(C(N[C@@H](C(C)(C)C)C(N2[C@H](C(N[C@H]3CC(O[C@H]3OCC)=O)=O)CCC2)=O)=O)=C1 |
| Target Point | Caspase-1 |
| Passage | Apoptosis |
| Background | It is a potent and selective caspase-1 inhibitor. |
| Biological Activity | Belnacasan是 VRT-043198 的口服前药，是一种有效，选择性的 caspase-1 抑制剂，Ki为0.8 nM[1-5]。 |
| Data Literature Source | [1]. Stack JH，et al. IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol. 2005 Aug 15;175(4):2630-4. [2]. Wannamaker W，et al. (S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3，3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R，3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765)，an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor，exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18. J Pharmacol Exp Ther. 2007 May;321(2):509-16. [3]. Ravizza T，et al. Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Epilepsia. 2006 Jul;47(7):1160-8. [4]. Xu Y，et al. NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain Behav Immun. 2016 Aug;56:175-86. [5]. Zhuang J，et al. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2'，4，4'-tetrabromodiphenyl ether (BDE-47)-treated mice. Brain Behav Immun. 2017 Oct;65:99-110 |
| Unit | Bottle |
| Specification | 5mg 10mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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