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(R)-(-)-Gossypol Acetic Acid

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Cat.No：IG2040 Solarbio

CAS：866541-93-7

Molecular Formula：C₃₂H₃₄O₁₀

Molecular Weight：578.61

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light brown to black Solid

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CAS	866541-93-7
Name	(R)-(-)-Gossypol Acetic Acid
Molecular Formula	C₃₂H₃₄O₁₀
Molecular Weight	578.61
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light brown to black Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.CC(O)=O.[R]
Target Point	Bcl-2 Family;Bcl-xL;Mcl-1
Passage	Apoptosis
Background	It is a potent inhibitor of Bcl-2,Bcl-xL and Mcl-1.
Biological Activity	(R)-(-)-Gossypol acetic acid (AT-101 (acetic acid)) 是天然产物 Gossypol 的左旋异构体。AT-101 结合到 Bcl-2，Mcl-1 和 Bcl-xL 蛋白，Ki 值分别为 260±30 nM，170±10 nM 和 480±40 nM。[1-2]
Data Literature Source	[1]. Oliver CL，et al. In vitro effects of the BH3 mimetic，(-)-Gossypol，on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63. [2]. Sun Y，et al. Apogossypolone，a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins，effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26.
Unit	Bottle
Specification	5mg 10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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