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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Apoptosis > Apoptosis Activator 2CAS：79183-19-0
Molecular Formula：C15H9Cl2NO2
Molecular Weight：306.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 79183-19-0 |
| Name | Apoptosis Activator 2 |
| Molecular Formula | C15H9Cl2NO2 |
| Molecular Weight | 306.14 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD00001743 |
| SMILES | O=C1N(CC2=CC=C(Cl)C(Cl)=C2)C3=C(C=CC=C3)C1=O |
| Target Point | Caspase activator |
| Passage | Apoptosis |
| Background | Apoptosis Activator 2 is a potent activator of apoptosis. |
| Biological Activity | Apoptosis Activator 2强诱导caspase-3激活， PARP分裂， DNA断裂，导致细胞破坏(Apaf-1依赖性的)，IC50约为4 μM，抑制HMEC， PREC和MCF-10A细胞活性。[1-4] |
| Data Literature Source | [1] Nguyen JT，et al. Proc Natl Acad Sci U S A，2003，100(13)，7533-7538. [2] Alavian KN，et al. Neural Dev，2009，16(4)，11. [3] Farivar TN，et al. N Am J Med Sci，2012，4(11)，582-585. [4] Nguyen TV，et al. J Neuroendocrinol，2010，22(9)，1013-1022. |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mg 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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