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Nutlin-3a

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Cat.No：IN0970 Solarbio

CAS：675576-98-4

Molecular Formula：C₃₀H₃₀Cl₂N₄O₄

Molecular Weight：581.49

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	675576-98-4
Name	Nutlin-3a
Molecular Formula	C₃₀H₃₀Cl₂N₄O₄
Molecular Weight	581.49
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD14636430
SMILES	O=C(N1C(C2=C(C=C(C=C2)OC)OC(C)C)=N[C@H]([C@H]1C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)N5CC(NCC5)=O
Target Point	MDM-2/p53
Passage	Apoptosis
Background	Nutlin 3a, the active isoform of Nutlin-3, is an MDM2 antagonist that inhibits the MDM2-p53 interaction and stabilizes p53 protein, thereby inducing cell cycle arrest and apoptosis.
Biological Activity	Nutlin-3a 是 Nutlin-3 的活性异构体，为一种鼠双微体 2 (MDM2) 拮抗剂，抑制 MDM2-p53 相互作用，且稳定 p53 蛋白，因此诱导细胞周期停滞和细胞凋亡[1-3]。
Data Literature Source	[1]. Crane EK，et al. Nutlin-3a: A Potential Therapeutic Opportunity for TP53 Wild-Type Ovarian Carcinomas. PLoS One. 2015 Aug 6;10(8):e0135101. [2]. Tovar C，et al. Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1888-93. [3]. M Ulrich，et al. Murine tumor models for the in vivo evaluation of natural compounds and their derivatives as new cancer therapeutics. München. 2016.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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